Cross-priming refers to the induction of primary cytotoxic CD8+ T cell responses to antigens that are not expressed in antigen presenting cells (APCs) responsible for T cell priming. Cross-priming is achieved through cross-presentation of exogenous antigens derived from tumors, extracellular pathogens or infected neighboring cells on Major Histocompatibility Complex (MHC) class I molecules. Despite extensive research efforts to understand the intracellular pathways involved in antigen cross-presentation, certain critical steps remain elusive and controversial. Here we review recent advances on antigen crosspresentation, focusing on the mechanisms involved in antigen export to the cytosol, a crucial step of this pathway.
CITATION STYLE
Gros, M., & Amigorena, S. (2019). Regulation of antigen export to the cytosol during cross-presentation. Frontiers in Immunology. Frontiers Media S.A. https://doi.org/10.3389/fimmu.2019.00041
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