Abstract
Chronic treatment of rats with clorgyline (1 mg/kg i.p. daily for 21 days) caused a highly significant increase in the concentration of noradrenaline in microdialysate from the frontal cortex of the awake animal. Acute (one injection, 2 mg/kg) or subacute (1 mg/kg daily for 3 days) treatment did not lead to a significant increase in microdialysate noradrenaline. Concentrations of deaminated metabolites (DPHG, MHPG, DOPAC) in the microdialysate decreased with time of treatment, reaching a minimum after 21 days.
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CITATION STYLE
Finberg, J. P. M., Pacak, K., Goldstein, D. S., & Kopin, I. J. (1994). Modification of cerebral cortical noradrenaline release by chronic inhibition of MAO-A. In Journal of Neural Transmission, Supplement (pp. 123–125). Springer-Verlag Wien. https://doi.org/10.1007/978-3-7091-9324-2_16
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