Antileukemic Agents. I: Some 2,5-Disubstituted p-Benzoquinones

Abstract

A series of p-benzoquinone derivatives having one or two carbamoyloxyalkyl groups in the 2 and/or 5-positions were synthesized and evaluated as antileukemic agents. Among these compounds 2,5-bis(l-aziridinyl)-3-(2-carbamoyloxyethyl)-6-methyl-p-benzoquinone (21) showed high activity against lymphoid leukemia L-1210 in BDF1 mice. © 1972, The Pharmaceutical Society of Japan. All rights reserved.