[Surgical Procedure for Subthalamic Nucleus Deep Brain Stimulation(STN-DBS)].

Abstract

Recently, deep brain stimulation(DBS)of the subthalamic nucleus(STN)has emerged as the most promising surgical treatment for medically refractory Parkinson disease, with the aim of achieving precise implantation of the DBS lead into the STN. DBS lead placement is performed using stereotactic surgery, with targeting based on MR imaging. Initial targeting is performed by a combination of indirect targeting based on the Schartenbrand and Wahren atlas and the direct visualization of anatomical structures on MRI. Surgical planning software is useful for target localization and simulation of the trajectory from the entry point to the target. A burr hole is placed under local anesthesia. Subsequently, the target region is physiologically explored by microelectrode recording, which is the gold standard to identify the STN. After lead placement, test stimulation is performed to assess symptom relief and to evaluate the threshold for adverse effects. Subsequently, the patient is placed under general anesthesia and the implantable pulse generator is placed in the infraclavicular subcutaneous pocket.