Abstract
An HPLC-MS/MS method for determining dabigatran in human blood serum was developed. Samples were prepared by precipitation of proteins using MeOH followed by centrifugation and dilution with deionized H2O. The developed method had a simple sample-preparation procedure, short analysis time, and wide analytical range (from 1 to 1,000 ng/mL). This method was suitable for routine bioanalytical studies, in particular, therapeutic drug monitoring.
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Rodina, T. A., Mel’nikov, E. S., Aksenov, A. A., Belkov, S. A., Sokolov, A. V., Prokof’ev, A. B., & Ramenskaya, G. V. (2018). HPLC-MS/MS Method for Determining Dabigatran in Human Blood Serum. Pharmaceutical Chemistry Journal, 51(12), 1129–1137. https://doi.org/10.1007/s11094-018-1753-1
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