Syntheses and Antibacterial Activity of 1-Oxacephem Derivatives.

2Citations
Citations of this article
1Readers
Mendeley users who have this article in their library.
Get full text

Abstract

Progress in synthetic studies on 1-oxacephems is reviewed. Antibacterial activity of this new class of compounds is also discussed briefly. Earlier syntheses, rather lengthy but quite pioneering, provided us with valuable information of the interesting biological activity of 1-oxaeephems. Several improved synthesis have appeared, enabling to prepare a variety of derivatives and examine their antibacterial activity. Thus, syntheses and antibacterial activity of oome interesting 1-oxacephems and 7 a-methoxy-l-oxacephems, such as, arylmalonamido-, n-acylureidophenylacetamido-, and a-amino-thiazolyl-a-methoxyiminoacetamido derivatives with representative 3r-substituents are described. A compound 6059-S 98 discovered in Shionogi Research Laboratories, proved to have excellent antibacterial activity, spectrum, and other pharmacological properties and, therefore, is currently under clinical studies. An industrially feasible synthetic method for its nucleus 88 a as well as 7a-methoxy-1-oxacephem nuclei with a variety of substituents at the 3'-position in general was established after extensive studies. © 1980, The Society of Synthetic Organic Chemistry, Japan. All rights reserved.

Cite

CITATION STYLE

APA

Nagata, W., & Narisada, M. (1980). Syntheses and Antibacterial Activity of 1-Oxacephem Derivatives. Yuki Gosei Kagaku Kyokaishi/Journal of Synthetic Organic Chemistry, 38(11), 1009–1024. https://doi.org/10.5059/yukigoseikyokaishi.38.1009

Register to see more suggestions

Mendeley helps you to discover research relevant for your work.

Already have an account?

Save time finding and organizing research with Mendeley

Sign up for free