Hepatitis B virus (HBV) infection is a common contributor to chronic hepatitis, liver cirrhosis, and hepatocellular carcinoma. Approximately 10% of people with human immunodeficiency virus (HIV) also have chronic HBV co-infection, owing to shared transmission routes. HIV/HBV coinfection accelerates the progression of chronic HBV to cirrhosis, end-stage liver disease, or hepatocellular carcinoma compared to chronic HBV mono-infection. HBV/HIV coinfection alters the natural history of hepatitis B and renders the antiviral treatment more complex. In this report, we conducted a critical review on the epidemiology, natural history, and pathogenesis of liver diseases related to HBV/HIV coinfection. We summarized the novel therapeutic options for these coinfected patients.
CITATION STYLE
Cheng, Z., Lin, P., & Cheng, N. (2021, October 4). HBV/HIV Coinfection: Impact on the Development and Clinical Treatment of Liver Diseases. Frontiers in Medicine. Frontiers Media S.A. https://doi.org/10.3389/fmed.2021.713981
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