Spleen as an organ at risk in adjuvant chemoradiotherapy for gastric cancer: a retrospective dosimetric study

Abstract

Introduction: This study aimed to determine the radiation dose to the spleen in adjuvant chemoradiotherapy for gastric cancer, resulting in haematological toxicities. Methods: This retrospective analysis of a prospectively maintained database was conducted at a tertiary referral cancer centre. All patients with biopsy-proven non-metastatic gastric adenocarcinoma planned for adjuvant chemoradiotherapy from January 2017 to December 2021 were included. The mean dose to the spleen (Dmean) was estimated and correlated with the development of haematological toxicities. Results: The mean spleen volume was 186•65 cc. The Dmean to the spleen was 35•35 Gy (20–42 Gy). Grade 3 leukopenia was observed in 67%, grade 4 in 15%, and grade 3 thrombocytopenia was noted in 41% of patients. Radiotherapy (RT) dose > 35•5 Gy to the spleen resulted in ≥ grade 3 leukopenia. RT dose ≥ 36•5 Gy resulted in grade 3 thrombocytopenia. The occurrence of leukopenia and thrombocytopenia was also affected by the location of the primary gastric cancer (higher incidence in distal than in proximal tumours). Conclusion: The spleen should be considered as an important organs at risk during adjuvant RT for gastric cancer. Dmean to the spleen should be < 35•5 Gy to prevent major haematological toxicities.