The transition from initiation to elongation by RNA polymerase II

Luse, D. S., & Samkurashvili, I. (1998). The transition from initiation to elongation by RNA polymerase II. In Cold Spring Harbor Symposia on Quantitative Biology (Vol. 63, pp. 289–300). Cold Spring Harbor Laboratory Press. https://doi.org/10.1101/sqb.1998.63.289

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The transition from initiation to elongation by RNA polymerase II

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The RNA polymerase II molecule at the 5′ end of the uninduced hsp70 gene of D. melanogaster is transcriptionally engaged

Basic mechanisms of transcript elongation and its regulation

The RNA-DNA hybrid maintains the register of transcription by preventing backtracking of RNA polymerase

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RNA polymerase is poised for activation across the genome

Spt5 and Spt6 are associated with active transcription and have characteristics of general elongation factors in D. melanogaster

Efficient release from promoter-proximal stall sites requires transcript cleavage factor TFIIS

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