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The HTLV-1 Tax interactome

Retrovirology
DOI: 10.1186/1742-4690-5-76
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Abstract

The Tax1 oncoprotein encoded by Human T-lymphotropic virus type I is a major determinant of viral persistence and pathogenesis. Tax1 affects a wide variety of cellular signalling pathways leading to transcriptional activation, proliferation and ultimately transformation. To carry out these functions, Tax1 interacts with and modulates activity of a number of cellular proteins. In this review, we summarize the present knowledge of the Tax1 interactome and propose a rationale for the broad range of cellular proteins identified so far. © 2008 Boxus et al; licensee BioMed Central Ltd.

Figures

  • Figure 3A illustrates Tax1 interactions with components of
  • Table 1: Cellular proteins interacting with Tax1
  • Table 1: Cellular proteins interacting with Tax1 (Continued)

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CITATION STYLE

APA

Boxus, M., Twizere, J. C., Legros, S., Dewulf, J. F., Kettmann, R., & Willems, L. (2008, August 14). The HTLV-1 Tax interactome. Retrovirology. https://doi.org/10.1186/1742-4690-5-76

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