Bupropion and Depressions

Abstract

Bupropion is a norepinephrine and dopamine reuptake inhibitor. It is indicated for the treatment of major depressive disorder, for the prevention of major depressive episodes in patients with seasonal affective disorder, and for the treatment of nicotine addiction (Food and Drug Administration, FDA). Positive effects on fatigue and hypersomnia have been described. Compared to other antidepressants, it has a positive side effect profile especially concerning the risk of weight gain, sexual dysfunction, and QT prolongation. At higher doses, there is an increased risk of seizures. Due to its unique pharmacology, it might be used for pharmacological augmentation of serotonergic antidepressants.