Impact of smoking on choroidal microvasculature dropout in glaucoma: a cross-sectional study

Abstract

Objective To investigate the effect of smoking on choroidal microvasculature dropout (MvD) in glaucoma. Design Cross-sectional study. Setting Tertiary glaucoma centre. Participants 223 eyes of 163 patients with primary open-angle glaucoma who had undergone imaging with optical coherence tomography angiography and completed a questionnaire on smoking from the Diagnostic Innovations in Glaucoma Study. Primary outcome measures Linear mixed-effects models were used to determine the effect of each parameter on MvD area and angular circumference. The sensitivity analysis was performed by categorising the glaucoma severity determined by visual field mean deviation (MD). Results MvD was found in 37 (51.4%) eyes with smoking history and in 67 (44.4%) eyes with nonsmokers (p=0.389). Larger MvD area and wider angular circumference were found in smokers compared with non-smokers (p=0.068 and p=0.046, respectively). In a multivariable model, smoking intensity was significantly associated with MvD area (0.30(95% CI 0.01 to 0.60) each 0.01 mm2 per 10 pack-years; p=0.044). In eyes with moderate-severe glaucoma (MD