The assessment of macular electrophysiology and macular morphology in patients with vitiligo

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Abstract

Purpose: We aimed to analyze the electrophysiologic function and morphology of macula in vitiligo patients. Methods: Seventeen patients with vitiligo and 11 healthy subjects were studied. All participants underwent multifocal electroretinography (mfERG) and spectral domain optical coherence tomography (SD-OCT) evaluations. The mfERG (P1 mfERG responses central and peripheral) and retinal layer segmentation parameters (nine ETDRS subfields) were compared in vitiligo and control groups. Results: The mean P1 response amplitudes were significantly decreased in central and peripheral rings of the fovea in patients with vitiligo compared with controls (p = 0.002 and p = 0.006, respectively). There was a tendency toward a prolonged mean implicit time for both central and peripheral in patients with vitiligo compared to controls, however, with no statistical significance (p = 0.453 and p = 0.05, respectively). There was no statistically significant difference in all retinal layers thickness between two groups. Conclusion: In patients with vitiligo, while photoreceptor segment preserved in SD-OCT, mfERG reduced showing potential decline in central retinal function. This study showed a potential decline in central retinal function in patients with vitiligo even if they have normal fundus appearance and SD-OCT findings.

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Aydin, R., Ozsutcu, M., Erdur, S. K., Dikkaya, F., Balevi, A., Ozbek, M., & Senturk, F. (2018). The assessment of macular electrophysiology and macular morphology in patients with vitiligo. International Ophthalmology, 38(1), 233–239. https://doi.org/10.1007/s10792-017-0452-3

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