Dismounting the MDR horse

38Citations
Citations of this article
18Readers
Mendeley users who have this article in their library.

This article is free to access.

Abstract

P-gp (also termed MDR1, or multidrug resistance-1) is a member of the membrane ATP cassette family that mediates efflux of several drugs commonly used to treat AML. Its expression has been correlated with an adverse outcome, 1 which was thought to occur because it mediates resistance to chemotherapy.

References Powered by Scopus

Benefit of cyclosporine modulation of drug resistance in patients with poor-risk acute myeloid leukemia: A Southwest Oncology Group study

368Citations
N/AReaders
Get full text

Phase 3 study of the multidrug resistance modulator PSC-833 in previously untreated patients 60 years of age and older with acute myeloid leukemia: Cancer and Leukemia Group B study 9720

323Citations
N/AReaders
Get full text

Mitoxantrone, etoposide, and cytarabine with or without valspodar in patients with relapsed or refractory acute myeloid leukemia and high-risk myelodysplastic syndrome: A phase III trial (E2995)

213Citations
N/AReaders
Get full text

Cited by Powered by Scopus

Revisiting the role of ABC transporters in multidrug-resistant cancer

1359Citations
N/AReaders
Get full text

Drug repurposing from an academic perspective

277Citations
N/AReaders
Get full text

Clinical Perspective of FDA Approved Drugs With P-Glycoprotein Inhibition Activities for Potential Cancer Therapeutics

102Citations
N/AReaders
Get full text

Register to see more suggestions

Mendeley helps you to discover research relevant for your work.

Already have an account?

Cite

CITATION STYLE

APA

Libby, E., & Hromas, R. (2010, November 18). Dismounting the MDR horse. Blood. American Society of Hematology. https://doi.org/10.1182/blood-2010-09-304311

Readers' Seniority

Tooltip

PhD / Post grad / Masters / Doc 9

75%

Professor / Associate Prof. 2

17%

Researcher 1

8%

Readers' Discipline

Tooltip

Agricultural and Biological Sciences 6

43%

Biochemistry, Genetics and Molecular Bi... 4

29%

Pharmacology, Toxicology and Pharmaceut... 2

14%

Medicine and Dentistry 2

14%

Save time finding and organizing research with Mendeley

Sign up for free