In this chapter, we describe a method for analyzing both recombinant and plasma-derived alpha 1 antitrypsin and its oligomers by means of native ion mobility mass spectrometry. Our experimental workflow can be applied to other variants of alpha 1 antitrypsin and its oligomers as well as being used to probe their interactions with small molecules in the gas phase.
CITATION STYLE
Vickers, S., Irving, J., Lomas, D. A., & Thalassinos, K. (2024). Native and Ion Mobility Mass Spectrometry Characterization of Alpha 1 Antitrypsin Variants and Oligomers. In Methods in Molecular Biology (Vol. 2750, pp. 41–55). Humana Press Inc. https://doi.org/10.1007/978-1-0716-3605-3_5
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