Spectrophotometric determination of ziprasidone hydrochloride in pharmaceutical formulations

Abstract

Two simple, sensitive, rapid and economical spectrophotometric methods (A&B) have been developed for the determination of ziprasidone hydrochloride in pharmaceutical bulk and tablet dosage form. Method A is based on the reaction of ziprasidone with ferric chloride and 1,10-phenanthroline to form blood red colored chromogen. Method B is based on the formation of blood red colored chromogen with ferric chloride and 2,2'-bipyridyl. The absorbances of the chromogens were measured at their respective wavelength of maximum absorbance against the corresponding reagent blank. The proposed methods have been successfully applied to the analysis of the bulk drug and its tablet dosage form. The methods have been statistically evaluated and were found to be precise and accurate.