Metallation of ligands with biological activity: Synthesis and X-ray characterization of polymeric [Cd(sulfamethoxazolato)2(CH 3OH)2]n·x(CH3OH)

Abstract

Sulfamethoxazole (5-methyl-3-isoxazolyl sulfanilamide) reacts with cadmium acetate in methanol in a steel autoclave at 150°C to give crystalline [Cd(sulfamethoxazolato)2(CH3OH)2] n·x(CH3OH) (1) the structure of which was characterized by single crystal X-ray diffraction. The triclinic crystals belong to the space group P1. In the polymeric assembly the Cd(II) centers are linked through sulfamethoxazolato anions which alternate in their coordination with the isoxazolic N-atoms and the aromatic amino groups. The chains of vicinal rings build tunnels along the crystallographic c axis. © 2005 Verlag der Zeitschrift für Naturforschung.