Monitoring Anticoagulation

Abstract

Monitoring coagulation is recommended only in specific situation, especially if standardised tests are available, which serves multiple purposes such as efficacy, assess bleeding, use of antidotes, and aid in drug selection. Coagulation assays may provide qualitative or quantitative assessment of the drug used. Laboratory measurements are dependent on several patient factors such as age, time when the last dose was taken, half-life and other factors affecting pharmacokinetics for the appropriate interpretation of the test results. Clinical monitoring along with noncoagulation laboratory monitoring also play a major role in many patient scenarios. This chapter gives information on the physiology, pharmacology and monitoring of anticoagulation.