Isoflurane has been reported to inhibit hypoxic pulmonary vasoconstriction. However, the effects of one-lung ventilation and isoflurane on regional pulmonary blood flow (Or) have not been investigated in detail. Therefore, using radionuclide labelled microspheres we measured Or in rabbits (n = 8) in the left lateral decubitus position during two- and one-lung ventilation under i.v, baseline anaesthesia and during additional administration of 1.5% isoflurane. Macrohaemodynamic variables were recorded continuously. Isoflurane increased non-dependent lung blood flow during two-lung ventilation. One-lung ventilation caused a homogeneous decrease in Or throughout the hypoxic lung, irrespective of isoflurane administration (P < 0.001). However, isoflurane significantly augmented Or of the hypoxic lung during one-lung ventilation (P < 0.05). During all phases, Or of the upper lobe was higher compared with that in the lower lobe in isogravitational slices of both lungs; a ventrodorsal perfusion gradient was found in the left upper robe. We conclude that 1.5% isoflurane increased perfusion of the non-dependent lung, inhibited hypoxic pulmonary vasoconstriction-induced redistribution of pulmonary blood flow and did not influence isogravitational perfusion gradients.
Mendeley helps you to discover research relevant for your work.
CITATION STYLE
Groh, J., Kuhnle, G. E. H., Ney, L., Sckell, A., & Goetz, A. E. (1995). Effects of isoflurane on regional pulmonary blood flow during one-lung ventilation. British Journal of Anaesthesia, 74(2), 209–216. https://doi.org/10.1093/bja/74.2.209