5‐ HT 7 receptor shapes spinogenesis in cortical and striatal neurons

Abstract

A review. The studies performed by Speranza et al. and other groups identify the 5-HT7R as a key player likely contributing not only to shaping neuronal circuitry during early life but also to remodelling of neuronal connectivity in the mature brain. These observations are of potential relevance for understanding and treating psychiatric disorders of neurodevelopmental origin and characterized by abroad range of cognitive deficits, such as autism spectrum disorders, depression and schizophrenia. [on SciFinder(R)]