Internal state estimation of arterial tree based on blood flow model

Abstract

Most non-invasive assessment techniques of arteriosclerosis have been proposed by assuming the blood vessels as simple cylindrical tubes. Although the arterial system has more complicated tree structure, previous assessment techniques do not take into account the spatial information of the arterial system. In this study, we propose a method in which the physical properties of whole arteries can be estimated from the observable states using Avolio's model. In order to evaluate the proposed method, we made a simulation analysis with the simplified arterial model. It was found that Young's modulus of various locations can be estimated from the observable state, pulse wave velocity. The results showed the proposed method has an ability to estimate the spatial information. It is also suggested that we need a customized optimization technique for the objective information and the observable state.