Numerous chemically different entities are clustered under the label of nonsteroidal anti-inflammatory drugs (NSAIDs). They share the ability to inhibit prostanoid synthesis by blocking the activity of the cyclooxygenase enzymes and, as a consequence, to exert anti-inflammatory, analgesic, and antipyretic effects. On the other hand, by hindering the housekeeping roles of prostaglandins, they also deteriorate the gastrointestinal mucosal barrier and the renal and endothelial hemodynamic regulation. The present chapter compiles available pharmacokinetic and pharmacodynamic data that may help to understand the different therapeutic profiles reported for particular agents.
CITATION STYLE
Calatayud, S., & Esplugues, J. V. (2016). Chemistry, pharmacodynamics, and pharmacokinetics of NSAIDs. In NSAIDs and Aspirin: Recent Advances and Implications for Clinical Management (pp. 3–16). Springer International Publishing. https://doi.org/10.1007/978-3-319-33889-7_1
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