The SNP rs931794 in 15q25.1 is associated with lung cancer risk: A hospital-based case-control study and meta-analysis

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Abstract

Background Lung cancer is one of the most common human malignant diseases and the leading cause of cancer death worldwide. The rs931794, a SNP located in 15q25.1, has been suggested to be associated with lung cancer risk. Nevertheless, several genetic association studies yielded controversial results. Methods and Findings A hospital-based case-control study involving 611 cases and 1062 controls revealed the variant of rs931794 was related to increased lung cancer risk. Stratified analyses revealed the G allele was significantly associated with lung cancer risk among smokers. Following meta-analysis including 6616 cases and 7697 controls confirmed the relevance of rs931794 variant with increased lung cancer risk once again. Heterogeneity should be taken into account when interpreting the consequences. Stratified analysis found ethnicity, histological type and genotyping method were not the sources of between-study heterogeneity. Further sensitivity analysis revealed that the study "Hsiung et al (2010)" might be the major contributor to heterogeneity. Cumulative meta-analysis showed the trend was increasingly obvious with adding studies, confirming the significant association. Conclusions Results from our current case-control study and meta-analysis offered insight of association between rs931794 and lung cancer risk, suggesting the variant of rs931794 might be related with increased lung cancer risk.

Figures

  • Table 1. The characteristics of the study population.
  • Table 2. Association between rs931794 and lung cancer risk in a Chinese population.
  • Table 3. The characteristics of included studies.
  • Table 4. Meta-analysis of the rs931794 in association with lung cancer risk.
  • Fig 1. The forest plots of OR with 95%CI for the rs931794 with lung cancer risk under dominant model. Fixed-effects pooled OR=1.14, 95%CI = 1.07-1.22, P<0.001; Pheterogeneity = 0.172.
  • Table 5. Sensitivity analysis of dominant model.
  • Fig 2. The cumulative meta-analysis of association rs931794 with lung cancer risk under dominant model.
  • Fig 3. The overall funnel plot under dominant model.

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Wang, Q., Ke, J., Song, Q., Hu, W., Lu, X., Wang, Z., … Zhu, Y. (2015). The SNP rs931794 in 15q25.1 is associated with lung cancer risk: A hospital-based case-control study and meta-analysis. PLoS ONE, 10(6). https://doi.org/10.1371/journal.pone.0128201

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