Pathology laboratory policies and procedures for releasing diagnostic tissue for cancer research

3Citations
Citations of this article
10Readers
Mendeley users who have this article in their library.

Abstract

Context.-The Surveillance, Epidemiology, and End Results (SEER) cancer registry program is currently evaluating the use of archival, diagnostic, formalin-fixed, paraffin-embedded (FFPE) tissue obtained through SEER cancer registries, functioning as honest brokers for deidentified tissue and associated data. To determine the feasibility of this potential program, laboratory policies for sharing tissue for research needed to be assessed. Objective.-To understand the willingness of pathology laboratories to share archival diagnostic tissue for cancer research and related policies. Design.-Seven SEER registries administered a 27-item questionnaire to pathology laboratories within their respective registry catchment areas. Only laboratories that processed diagnostic FFPE specimens and completed the questionnaire were included in the analysis. Results.-Of the 153 responding laboratories, 127 (83%) responded that they process FFPE specimens. Most (n ¼ 88; 69%) were willing to share tissue specimens for research, which was not associated with the number of blocks processed per year by the laboratories. Most laboratories retained the specimens for at least 10 years. Institutional regulatory policies on sharing deidentified tissue varied considerably, ranging from requiring a full Institutional Review Board review to considering such use exempt from Institutional Review Board review, and 43% (55 of 127) of the laboratories did not know their terms for sharing tissue for research. Conclusions.-This project indicated a general willingness of pathology laboratories to participate in research by sharing FFPE tissue. Given the variability of research policies across laboratories, it is critical for each SEER registry to work with laboratories in their catchment area to understand such policies and state legislation regulating tissue retention and guardianship.

References Powered by Scopus

A new initiative on precision medicine

3859Citations
N/AReaders
Get full text

Robustness of next generation sequencing on older formalin-fixed paraffin-embedded tissue

89Citations
N/AReaders
Get full text

Estimation of age-related DNA degradation from formalin-fixed and paraffin-embedded tissue according to the extraction methods

58Citations
N/AReaders
Get full text

Cited by Powered by Scopus

Unveiling the arcanum of formalin-fixed paraffin-embedded archival tissue blocks: A valuable resource for genomic DNA extraction

6Citations
N/AReaders
Get full text

snPATHO-seq, a versatile FFPE single-nucleus RNA sequencing method to unlock pathology archives

0Citations
N/AReaders
Get full text

NCI SEER-Linked Virtual Tissue Repository Pilot

0Citations
N/AReaders
Get full text

Register to see more suggestions

Mendeley helps you to discover research relevant for your work.

Already have an account?

Cite

CITATION STYLE

APA

Yuan, Y., van Dyke, A. L., Petkov, V. I., Hussey, S., Moravec, R., Altekruse, S. F., … Penberthy, L. S. (2021). Pathology laboratory policies and procedures for releasing diagnostic tissue for cancer research. Archives of Pathology and Laboratory Medicine, 145(2), 222–226. https://doi.org/10.5858/arpa.2019-0474-OA

Readers over time

‘21‘22‘23‘2401234

Readers' Seniority

Tooltip

Professor / Associate Prof. 1

50%

PhD / Post grad / Masters / Doc 1

50%

Readers' Discipline

Tooltip

Medicine and Dentistry 2

50%

Pharmacology, Toxicology and Pharmaceut... 1

25%

Social Sciences 1

25%

Save time finding and organizing research with Mendeley

Sign up for free
0