Regulatory T-cells (Treg) are considerably heterogeneous. Thymically derived Treg (tTreg) are those, which differentiate in the thymus, while peripherally derived Treg (pTreg) differentiate from peripheral mature CD4+ T-cells. These two populations are often identified using markers such as neuropilin-1 and Helios (for tTreg) and ROR-γt (for pTreg) in intestines (Tanoue et al., Nat Rev Immunol 16:295–309, 2016).
CITATION STYLE
Tan, B. J. Y., Ono, M., & Satou, Y. (2023). Single-Cell Transcriptome Analysis of Treg. In Methods in Molecular Biology (Vol. 2559, pp. 259–278). Humana Press Inc. https://doi.org/10.1007/978-1-0716-2647-4_17
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