Heart rate response to cognitive load as a marker of depression and increased anxiety

Abstract

Introduction: Understanding the interplay between cardiovascular parameters, cognitive stress induced by increasing load, and mental well-being is vital for the development of integrated health strategies today. By monitoring physiological signals like electrocardiogram (ECG) and photoplethysmogram (PPG) in real time, researchers can discover how cognitive tasks influence both cardiovascular and mental health. Cardiac biomarkers resulting from cognitive strain act as indicators of autonomic nervous system function, potentially reflecting conditions related to heart and mental health, including depression and anxiety. The purpose of this study is to investigate how cognitive load affects ECG and PPG measurements and whether these can signal early cardiovascular changes during depression and anxiety disorders. Methods: Ninety participants aged 18 to 45 years, ranging from symptom-free individuals to those with diverse psychological conditions, were assessed using psychological questionnaires and anamnesis. ECG and PPG monitoring were conducted as volunteers engaged in a cognitive 1-back task consisting of two separate blocks, each with six progressively challenging levels. The participants’ responses were analyzed to correlate physiological and psychological data with cognitive stressors and outcomes. Results: The study confirmed a notable interdependence between anxiety and depression, and cardiovascular responses. Task accuracy decreased with increased task difficulty. A strong relationship between PPG-measured heart rate and markers of depression and trait anxiety was observed. Increasing task difficulty corresponded to an increase in heart rate, linked with elevated levels of depression and trait anxiety. A strong relationship between ECG-measured heart rate and anxiety attacks was observed. Increasing task difficulty corresponded to an increase in heart rate, linked with elevated levels of anxiety attacks, although this association decreased under more challenging conditions. Discussion: The findings underscore the predictive importance of ECG and PPG heart rate parameters in mental health assessment, particularly depression and anxiety under cognitive stress induced by increasing load. We discuss mechanisms of sympathetic activation explaining these differences. Our research outcomes have implications for clinical assessments and wearable device algorithms for more precise, personalized mental health diagnostics.