Replacement of the single cysteine residue (C192) with serine in the Streptococcus pyogenes extracellular cysteine protease (SCP) prevented auto- catalytic processing of the 40-kDa zymogen to the 28-kDa mature form and eliminated proteolytic activity. SCP incubated with human endothelial cells induced a time- and concentration-dependent increase in a 66-kDa gelatinase/type IV collagenase in culture supernatants. Activation of this gelatinase/collagenase may contribute to endothelial cell damage, tissue destruction, and hemodynamic derangement observed in some patients with severe, invasive S. pyogenes infection.
CITATION STYLE
Burns, E. H., Marciel, A. M., & Musser, J. M. (1997). Structure-function and pathogenesis studies of streptococcus pyogenes extracellular cysteine protease. In Advances in Experimental Medicine and Biology (Vol. 418, pp. 589–592). Springer New York LLC. https://doi.org/10.1007/978-1-4899-1825-3_136
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