Dendritic cells (DCs) are key regulators of immune responses that operate at the interface between innate and adaptive immunity, and defects in DC functions contribute to the pathogenesis of a variety of disorders. For instance, cancer evolves in the context of limited DC activity, and some autoimmune diseases are initiated by DC-dependent antigen presentation. Thus, correcting aberrant DC functions stands out as a promising therapeutic paradigm for a variety of diseases, as demonstrated by an abundant preclinical and clinical literature accumulating over the past two decades. However, the therapeutic potential of DC-targeting approaches remains to be fully exploited in the clinic. Here, we discuss the unique features of DCs that underlie the high therapeutic potential of DC-targeting strategies and critically analyze the obstacles that have prevented the full realization of this promising paradigm.
CITATION STYLE
Fucikova, J., Palova-Jelinkova, L., Bartunkova, J., & Spisek, R. (2019). Induction of tolerance and immunity by dendritic cells: Mechanisms and clinical applications. Frontiers in Immunology. Frontiers Media S.A. https://doi.org/10.3389/fimmu.2019.02393
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