Models for angiogenesis

Abstract

There are many systems which can serve as models for assessing angiogenic responses, both in vivo and in vivo. Each model has its advantages and disadvantages, its problems, technical difficulties and limitations, as well as its beneficial features. In this review we evaluate the major test systems currently in use, with special emphasis on comparing cell cultures, organ explants, whole embryo cultures and in vivo assay systems. © 2008 Springer US.