We report a case of a 59-year-old male diagnosed with extensive-stage small cell lung cancer (SCLC). He received first-line platinum doublet chemotherapy and second-line topotecan-based regimen, but experienced disease progression after each line of therapy. He was then treated with Sintilimab, a PD-1 inhibitor, in combination with nab-paclitaxel in the third-line setting, which resulted in significant tumor shrinkage. Restaging scans showed a partial response per RECIST criteria with 62% reduction in tumor burden. This case highlights the application and efficacy of immune checkpoint inhibitors in extensive-stage SCLC.
CITATION STYLE
Yuan, G., Liu, X., Zhang, X., Song, W., Lu, J., Ding, Z., & Chen, X. (2023). Remarkable response to PD-1 inhibitor in a patient with extensive-stage small cell lung cancer: a case report and literature review. Frontiers in Immunology, 14. https://doi.org/10.3389/fimmu.2023.1267606
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