Protective effect of methylprednisolone on ventilator-induced diaphragm dysfunction is dose dependent

Abstract

Administration of 80 mg/kg methylprednisolone has been shown to prevent controlled mechanical ventilation (CMV) diaphragm dysfunction in rats, partly by inhibiting the calpain system [1]. The current experiments determined whether lower doses of corticosteroids will also provide protection against ventilator-induced diaphragm dysfunction.