Minerals substituted apatite (M-HA) nanoparticles were prepared by the precipitation of minerals and phosphate reactants in choline chloride-Thiourea (ChCl–TU) deep eutectic solvent (DESs) as a facile and green way approach. After preparation of nanoparticles (F-M-HA (F = Fresh solvent)), the DESs was recovered productively and reprocess for the preparation of R-M-HA nanoparticles (R = Recycle solvent).The functional groups, phase, surface texture and the elemental composition of the M-HA nanoparticles were evaluated by advance characterization methods. The physicochemical results of the current work authoritative the successful uses of the novel (ChCl–TU) DESs as eco-friendly recuperate and give the medium for the preparation of M-HA nanoparticles. Moreover, the as-synthesized both M-HA nanoparticles exhibit excellent biocompatibility, consisting of cell co-cultivation and cell adhesion, in vivo according to surgical implantation of Wistar rats.
CITATION STYLE
Govindaraj, D., Rajan, M., Munusamy, M. A., Alarfaj, A. A., Sadasivuni, K. K., & Kumar, S. S. (2017). The synthesis, characterization and in vivo study of mineral substituted hydroxyapatite for prospective bone tissue rejuvenation applications. Nanomedicine: Nanotechnology, Biology, and Medicine, 13(8), 2661–2669. https://doi.org/10.1016/j.nano.2017.07.017
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