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Gut Metabolite Urolithin A Inhibits Osteoclastogenesis and Senile Osteoporosis by Enhancing the Autophagy Capacity of Bone Marrow Macrophages

Frontiers in Pharmacology (2022) 13
DOI: 10.3389/fphar.2022.875611
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Abstract

Uro-A, which is a metabolite of intestinal flora and mainly produced from pomegranates and some nuts, suppresses osteoclast formation and bone resorption by activating autophagy. Uro-A upregulated the expression of Beclin 1 and LC3 and modulated bone homeostasis 4 in BMMs, thus resulting in decreased osteoclast-related markers and bone loss. (Figure presented.)

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CITATION STYLE

APA

Tao, H., Tao, Y., Yang, C., Li, W., Zhang, W., Li, X., … Geng, D. (2022). Gut Metabolite Urolithin A Inhibits Osteoclastogenesis and Senile Osteoporosis by Enhancing the Autophagy Capacity of Bone Marrow Macrophages. Frontiers in Pharmacology, 13. https://doi.org/10.3389/fphar.2022.875611

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