Pregabalin is a gabapentinoid that was first developed as an antiepileptic agent. However, after its release, off-label prescriptions for conditions other than epilepsy made up about 90% of pregabalin’s use. Pregabalin was later approved for the management of anxiety disorders and is one of the first pharmacotherapies considered for the management of neuropathic pain. Pregabalin is commonly used in the treatment of generalized anxiety disorder and has evidence in the treatment of social anxiety disorder, obsessive-compulsive disorder, and posttraumatic stress disorder. Additionally, pregabalin is widely used for the management of pain disorders. Pregabalin has been studied for several decades and evidence shows that any adverse effects associated with its use are generally well tolerated. Pregabalin is only associated with benign central nervous system and systemic adverse effects. There are a very limited number of reported metabolic, idiosyncratic, and known teratogenic adverse effects. In this chapter, we will review the mechanism of action for pregabalin, its indication of use in different anxiety disorders, and the potential adverse effects.
CITATION STYLE
Alavi, N., & Stephenson, C. (2022). Tranquilizer/Anxiolytics: Pregabalin. In NeuroPsychopharmacotherapy (pp. 2083–2097). Springer International Publishing. https://doi.org/10.1007/978-3-030-62059-2_166
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