Involvement of reactive oxygen species in phospholipase A2 activation: Inhibition of protein tyrosine phosphatases and activation of protein kinases

Abstract

Activators of PKC in combination with vanadate induce massive formation of reactive oxygen species. The formation of ROS leads to suppression of protein tyrosine phosphatase activity and consequently to enhanced protein tyrosine phosphorylation. This culminates in the activation of the MAP-K cascade and of PLA2 (Scheme 1).