The Hippo Signaling Pathway: A Candidate New Drug Target for Malignant Tumors

Abstract

This is a short summary of my presentation in the Uehara Memorial Foundation Symposium 2014. Classifi cation of mental illness in current diagnostic systems [such as the Diagnostic and Statistical Manual of Mental Disorders (DSM)] is built on clinical reliability and utility, but not on etiological validity. Thus, the DSM has not provided an ideal classifi cation of mental disorders. To overcome the dilemma, the National Institute of Mental Health (NIMH) recently proposed the Research Domain Criteria (RDoC) framework. This new framework emphasizes a dimensional approach on the basis of neurocircuitry mechanism. There were three aims in my presentation. First, I summarized the concept of research strategies on the basis of dimensional approach, with a link to the trajectory from early develop- ment to adolescence in the disease pathology. Second, I introduced an example of a research infrastructure that could support translational and clinical study for mental illness. Third, I showed two studies that were utilizing the infrastructure. Keywords