Previous studies and our findings suggest upregulated expression of proinflammatory chemokines CCL3/4 in germinal center (GC) centrocytes. However, the role of CCL3/4 for centrocyte interactions with follicular T cells and regulation of humoral immunity is poorly understood. We found that CCL3 promotes chemotaxis of Tfr cells ex vivo. Two-photon imaging revealed that B cells-intrinsic production of CCL3 promotes their probing by follicular regulatory T cells (Tfr) within GCs of murine lymph nodes. Overall this study suggests that CCL3 facilitates direct interactions of foreign antigen-specific GC B cells and their negative regulation with Tfr cells in vivo.
CITATION STYLE
Benet, Z. L., Marthi, M., Ke, F., Wu, R., Turner, J. S., Gabayre, J. B., … Grigorova, I. L. (2018). CCL3 promotes germinal center B cells sampling by follicular regulatory T cells in murine lymph nodes. Frontiers in Immunology, 9(SEP). https://doi.org/10.3389/fimmu.2018.02044
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