Ventilator-induced kidney injury: Are novel biomarkers the key to prevention?

46Citations
Citations of this article
55Readers
Mendeley users who have this article in their library.
Get full text

Abstract

Mechanical ventilation is associated with significant increases in the risk of acute kidney injury (AKI). The rate of AKI due to mechanical ventilation and the associated mortality remain unacceptably high. Preventative and therapeutic strategies are clearly lacking. Ventilator-induced kidney injury is believed to occur due to changes in hemodynamics that impair renal perfusion, neurohumoral-mediated alterations in intra-renal blood flow, and systemic inflammatory mediators generated by ventilator-induced lung injury. The risk of injury to the kidney by these mechanisms may be modified by open lung protective ventilation with low tidal volumes and high positive end expiratory pressure. However, these strategies may also increase the risk of injury in some settings, and clinicians have limited means to identify the optimal ventilator strategy for each specific patient. Novel urinary biomarkers have demonstrated the ability to predict AKI prior to classic clinical signs such as decreased urine output and increased creatinine. These biomarkers may serve as an early indication to intensivists of an injurious ventilator strategy and failure of traditional management.

References Powered by Scopus

Ventilation with lower tidal volumes as compared with traditional tidal volumes for acute lung injury and the acute respiratory distress syndrome

11291Citations
N/AReaders
Get full text

Discovery and validation of cell cycle arrest biomarkers in human acute kidney injury

1065Citations
N/AReaders
Get full text

Injurious Mechanical Ventilation and End-Organ Epithelial Cell Apoptosis and Organ Dysfunction in an Experimental Model of Acute Respiratory Distress Syndrome

613Citations
N/AReaders
Get full text

Cited by Powered by Scopus

Immunity, endothelial injury and complement-induced coagulopathy in COVID-19

454Citations
N/AReaders
Get full text

A prediction and interpretation framework of acute kidney injury in critical care

34Citations
N/AReaders
Get full text

Acute Kidney Injury in Sepsis

30Citations
N/AReaders
Get full text

Register to see more suggestions

Mendeley helps you to discover research relevant for your work.

Already have an account?

Cite

CITATION STYLE

APA

Hepokoski, M. L., Malhotra, A., Singh, P., & Crotty Alexander, L. E. (2018, September 1). Ventilator-induced kidney injury: Are novel biomarkers the key to prevention? Nephron. S. Karger AG. https://doi.org/10.1159/000491557

Readers' Seniority

Tooltip

PhD / Post grad / Masters / Doc 15

63%

Researcher 4

17%

Professor / Associate Prof. 3

13%

Lecturer / Post doc 2

8%

Readers' Discipline

Tooltip

Medicine and Dentistry 22

79%

Nursing and Health Professions 3

11%

Agricultural and Biological Sciences 2

7%

Chemical Engineering 1

4%

Save time finding and organizing research with Mendeley

Sign up for free