Synthesis of Sulfated Cerebroside Analogs having Mimicks of Ceramide and their Anti-human Immunodeficiency Virus Type 1 Activities

Abstract

Various sulfated cerebroside analogs, which are mimicks of cerebroside, have been prepared from per-O-acetylated D-glucose, per-O-acetylated D-galactose, and per-O-acetylated D-lactose with ethyleneglycol dodecyl ether, 3-docosyloxy-1-propanol, 2-hydroxymethyl-1,3-O-dimyristyl-1,3-propanediol, and L-serine diamide derivatives as ceramide moieties. The synthesized sulfated glycolipids showed anti-HIV-1 activities. © 1995, The Pharmaceutical Society of Japan. All rights reserved.