Pancreatic ductal adenocarcinoma (PDAC) is an aggressive malignant tumor with a high metastatic potential. Perineural invasion (PNI) occurs in the early stages of PDAC with a high incidence rate and is directly associated with a poor prognosis. It involves close interaction among PDAC cells, nerves and the tumor microenvironment. In this review, we detailed discuss PNI-related pain, six specific steps of PNI, and treatment of PDAC with PNI and emphasize the importance of novel technologies for further investigation.
CITATION STYLE
Sun, Y., Jiang, W., Liao, X., & Wang, D. (2024). Hallmarks of perineural invasion in pancreatic ductal adenocarcinoma: new biological dimensions. Frontiers in Oncology. Frontiers Media SA. https://doi.org/10.3389/fonc.2024.1421067
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