Abstract
Altered H2S levels and intracellular viscosity have both been seen in Parkinson's disease (PD). However, how H2S and intracellular viscosity are involved in PD pathogenesis remains unknown. Herein, a dual-function fluorescent probe DF was designed and synthesized to analyze intracellular viscosity and hydrogen sulfide. It is a near-infrared fluorescence probe with improved photostability and large Stokes shift (110 nm). The probe reveals increased viscosity and hydrogen sulfide in zebrafish model of PD for the first time.
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Shen, W., Wang, P., Xie, Z., Zhou, H., Hu, Y., Fu, M., & Zhu, Q. (2021). A bifunctional probe reveals increased viscosity and hydrogen sulfide in zebra fish model of Parkinson’s disease. Talanta, 234. https://doi.org/10.1016/j.talanta.2021.122621
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