The exponential escalation of dengue cases has indeed become a global health crisis. This work elaborates on the development of a biofunctionalized tapered optical fiber (TOF) based sensor with the integration of polyamidoamine (PAMAM) dendrimer for the detection of dengue E protein. The dimension of the TOF generated an evanescent field that was sensitive to any changes in the external medium while the integration of PAMAM promoted more adhesion of bio-recognition molecules; anti-DENV II E protein antibodies; that were complementary to the targeted protein. This in return created more active sites for the absorption of DENV II E proteins onto the tapered region. The resolution and detection limit of the sensor are 19.53 nm/nM and 1 pM, respectively with Kd = 1.02 × 10−10 M.
CITATION STYLE
Mustapha Kamil, Y., Al-Rekabi, S. H., Yaacob, M. H., Syahir, A., Chee, H. Y., Mahdi, M. A., & Abu Bakar, M. H. (2019). Detection of dengue using PAMAM dendrimer integrated tapered optical fiber sensor. Scientific Reports, 9(1). https://doi.org/10.1038/s41598-019-49891-7
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