Interleukin (IL)-4 plays a central role in determining the phenotype of naïve CD4+ T cells by promoting their differentiation into IL-4-producing T helper type 2 (Th2) cells, which are crucial for the induction of allergic inflammation. However, to date, the potential sources of "primary IL-4" in vivo, as distinguished from IL-4 produced by Th2 cells, remain unclear. Here, I describe the research I carried out in collaboration with Dr. William E. Paul to identify "primary IL-4"-producing cells and Th2 cell differentiation in vivo.
CITATION STYLE
Yoshimoto, T. (2018, April 23). The hunt for the source of primary interleukin-4: How we discovered that natural killer T cells and basophils determine T helper type 2 cell differentiation in vivo. Frontiers in Immunology. Frontiers Media S.A. https://doi.org/10.3389/fimmu.2018.00716
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