Penetration of topically administered 0.5-percent caspofungin eye drops into human aqueous humor

Abstract

Ten participants attending elective anterior segment eye surgery received 0.5% caspofungin eye drops either 1 drop hourly for 4 h or 1 drop an hour before surgery. The eye drops were generally well tolerated. In the absence of inflammation or corneal abrasion, topical caspofungin does not achieve clinically relevant concentrations. Copyright © 2011, American Society for Microbiology. All Rights Reserved.