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Resistance to voriconazole due to a G448S substitution in Aspergillus fumigatus in a patient with cerebral aspergillosis

Journal of Clinical Microbiology (2012) 50(7) 2531-2534
DOI: 10.1128/JCM.00329-12
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Abstract

A voriconazole-resistant isolate of Aspergillus fumigatus was recovered from an immunocompetent patient receiving long-term antifungal therapy for cerebral aspergillosis. A G448S amino acid substitution in the azole target (Cyp51A) was identified as the cause of the resistance phenotype. This article describes the first isolation of a voriconazole-resistant A. fumigatus isolate from an immunocompetent patient in Spain. Copyright © 2012, American Society for Microbiology. All Rights Reserved.

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CITATION STYLE

APA

Pelaez, T., Gijón, P., Bunsow, E., Bouza, E., Sánchez-Yebra, W., Valerio, M., … Melladod, E. (2012). Resistance to voriconazole due to a G448S substitution in Aspergillus fumigatus in a patient with cerebral aspergillosis. Journal of Clinical Microbiology, 50(7), 2531–2534. https://doi.org/10.1128/JCM.00329-12

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