Targeting oncogenic vulnerabilities in triple negative breast cancer: Biological bases and ongoing clinical studies

38Citations
Citations of this article
74Readers
Mendeley users who have this article in their library.

Abstract

Triple negative breast cancer (TNBC) is still an incurable disease despite the great scientific effort performed during the last years. The huge heterogeneity of this disease has motivated the evaluation of a great number of therapies against different molecular alterations. In this article, we review the biological bases of this entity and how the known molecular evidence supports the current preclinical and clinical development of new therapies. Special attention will be given to ongoing clinical studies and potential options for future drug combinations.

References Powered by Scopus

The protein kinase complement of the human genome

6809Citations
N/AReaders
Get full text

Identification of human triple-negative breast cancer subtypes and preclinical models for selection of targeted therapies

4167Citations
N/AReaders
Get full text

Triple-negative breast cancer: Clinical features and patterns of recurrence

3990Citations
N/AReaders
Get full text

Cited by Powered by Scopus

Recent therapeutic trends and promising targets in triple negative breast cancer

180Citations
N/AReaders
Get full text

Activity of BET-proteolysis targeting chimeric (PROTAC) compounds in triple negative breast cancer

77Citations
N/AReaders
Get full text

Overcoming Cancer Drug Resistance Utilizing PROTAC Technology

62Citations
N/AReaders
Get full text

Register to see more suggestions

Mendeley helps you to discover research relevant for your work.

Already have an account?

Cite

CITATION STYLE

APA

Ocana, A., & Pandiella, A. (2017). Targeting oncogenic vulnerabilities in triple negative breast cancer: Biological bases and ongoing clinical studies. Oncotarget. Impact Journals LLC. https://doi.org/10.18632/oncotarget.14731

Readers' Seniority

Tooltip

PhD / Post grad / Masters / Doc 22

63%

Researcher 7

20%

Professor / Associate Prof. 5

14%

Lecturer / Post doc 1

3%

Readers' Discipline

Tooltip

Medicine and Dentistry 17

40%

Biochemistry, Genetics and Molecular Bi... 17

40%

Pharmacology, Toxicology and Pharmaceut... 5

12%

Agricultural and Biological Sciences 4

9%

Save time finding and organizing research with Mendeley

Sign up for free