Isolation, structure elucidation, and biological activity of flavone 6-C-glycosides from Alliaria petiolata

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Abstract

Preparative reversed-phase HPLC analysis of a methanol extract of the seeds of Alliaria petiolata afforded fourflavone 6-C-glycosides: isoorientin, swertiajaponin, swertisin and isoscoparin-2″-β-D-glucopyranoside. The molecular structures were elucidated by UV, ESIMS and comprehensive 1D ( 1H and 13 C) and 2D (gradient multiple quantum filtered 1H-1H COSY, 1H-13C HSQC and 1H-13C HMBC) NMR analyses. The antibacterial and free radical scavenging activity, and general toxicity of these compounds were assessed. While none of these glycosides showed any significant antibacterial activities at test concentrations, all these compounds showed prominent free radical scavenging activity (IC50 values: 1.25×10-2 to 7.69×10-3 mg/mL) in DPPH assay. In the brine shrimp lethality assay very low levels of general toxicity (LD50 >1.00 mg/mL) were displayed.

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Kumarasamy, Y., Byres, M., Cox, P. J., Delazar, A., Jaspars, M., Nahar, L., … Sarker, S. D. (2004). Isolation, structure elucidation, and biological activity of flavone 6-C-glycosides from Alliaria petiolata. Chemistry of Natural Compounds, 40(2), 122–128. https://doi.org/10.1023/B:CONC.0000033926.72396.41

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